1026. CHRONOMODULATED NIFEDIPINE ADMINISTRATION AND MICROVASCULAR COMPLICATIONS IN GLIMEPIRIDE-TREATED HYPERGLYCAEMIC RATS
ABSTRACT
Diabetic complications pose increasing public health problems worldwide. Glimepiride, a sulphonylurea is among the most frequently used anti-diabetic drugs, and is often combined with other drugs for the management of type 2 diabetes mellitus. Nifedipine, a calcium channel blocker is recommended for its role in mitigating microvascular complications especially in delaying the onset of diabetic nephropathy. Interaction between both drugs leads to regimen failure when simulta...