301. EVALUATION OF THE DISSOLUTION AND OTHER CHARACTERISTICS OF CYCLODEXTRIN MOLECULAR INCLUSION COMPLEXES OF ARTEMETHER

ABSTRACT

The present study aimed to improve the dissolution rate, solubility and ultimately, bioavailability of poorly soluble artemether, an antimalarial drug, through inclusion complex formation with hydroxypropyl-β-cyclodextrin.

The solid complexes of artemether and hydroxypropyl-β-cyclodextrin (HP-β-CD) were prepared at a molar ratio of 1:1, 1:2 and 1:3 by kneading method. The effect of HP-β-CD on the aqueous solubility and dissolution rate of artem...

302. EVALUATION OF THE BIODIESEL POTENTIALS OF SELECTED PLANT BIOMASSES IN IBADAN NORTH LOCAL GOVERNMENT AREA, NIGERIA

ABSTRACT

There has been an increasing emphasis on renewable sources of energy following recurrent economic crises and environmental concerns associated with petrodiesel. In Nigeria, there is an abundance of oil-bearing inedible plant biomasses, which are underutilized. Research into biodiesel production from these renewable oil sources can provide a more sustainable alternative to petrodiesel. This study was designed to evaluate the biodiesel yielding potentials of selected locally...

303. EVALUATION OF THE BINDING PROPERTIES OF ENZYME - HYDROLYZED CASSAVA STARCH IN CHLOROQUINE PHOSPHATE TABLET FORMULATIONS

ABSTRACT

Starch is a major carbohydrate, easily extractable from various sources like cassava, maize, potato etc which find wide application in various food and Pharmaceutical industries. There has been a lot of attempt to modify this highly flexible polymer with the aim of extending and enhancing its applications.

Native cassava starch (NCS) was extracted from the tubers of freshly harvested cassava. Enzyme- hydrolysed starch (EHS) was produced from Native cassava starch...

304. EVALUATION OF THE BINDING AND SUSPENDING PROPERTIES OF BAGGASE-DERIVED METHYLCELLULOSE

ABSTRACT

Sourcing of raw materials for use in pharmaceutical industries is a continuing challenge. Excipients, which form the bulk of a dosage form, are derived either from natural sources or synthesized wholly or semi-synthesized. The absence of an ideal excipient material continues to spur research towards identifying and developing excipients from various sources. One of such potential sources is sugar cane bagasse which is an abundant agricultural waste. This work, investigated...

305. EVALUATION OF THE ANTIMICROBIA; ANTIOXIDANT AND STAINING PROPERTIES OF SIX INDIGENOUNS PLANTS EXTRACTS COLLECTED FROM SOUTHERN NIGERIA

1.0Background of Study

The Nigeria climate favours a great array of plant species many of which have varied medicinal and antimicrobial potentials (Adewusi, 1997; Adeuse-Poku et al., 2003; Ajebesone and Aina, 2004, Agyili et al., 2006). It is estimated that there are over 65,000 species of flowering plants that have medicinal properties (Akpulu et al., 1994; Akoachere et al., 2002, Akinpelu and Kolawole 2004). The vast medicinal use of plants is attributed to the abundant quantity o...

306. EVALUATION OF THE ANTI-FUNGAL ACTIVITIES OF CRUDE EXTRACTS OF THE AERIAL PARTS OF MITRACARPUS VILLOSUS (Sw.) DC.

ABSTRACT

Plants have provided a source for novel drug compounds, as plant derived medicines have made large contributions to human health and well-being. The aerial parts of Mitracarpus villosus were powdered, screened for phyto-compounds and the phyto- compounds detected were isolated. This was followed by successive extraction of the plant (hexane, ethyl acetate, ethanol and water) and fractionation of the ethyl acetate extract. Antifungal activities of the crude extracts, fractio...

307. EVALUATION OF TABLETING PROPERTIES OF NATIVE AND MODIFIED STARCHES, DERIVED FROM SOLENOSTEMON ROTUNDIFOLIUS, AS TABLET BINDER AND DISINTEGRANT

ABSTRACT

The aim of this research was to study the tableting properties of Solenostemon rotundifolius starch (SRS) and modified forms for use as pharmaceutical excipient by wet granulation method of tablet production in paracetamol formulation.

The physicochemical properties of native and modified starches were investigated and compared with Maize starch B.P. (MZS). Properties of granules and tablets formulated with various experimental starches and gelatin (GLT) tested as...

308. EVALUATION OF TABLETING PROPERTIES OF CRUDE TURMERIC (CURCUMA LONGA LINN) POWDER

ABSTRACT

The aim of this work is to formulate crude turmeric powder into tablet form. The powder was produced from the turmeric rhizome. Physicochemical properties of the powder; angle of repose (AR), bulk density (BD), tapped density (TD), Hausner‟s ratio (HR), Carr‟s index (CI), true density, moisture content, and flow rate (FR) were evaluated. The particles size and morphology were determined using Scanning electron microscope and sieve analysis. The tablets were formulated using...

309. EVALUATION OF TABLETING AND COMPRESSIONAL CHARACTERISTICS OF NATIVE AND MICROCRYSTALLINE STARCHES DERIVED FROM DIGITARIA IBURUA.

ABSTRACT

Acid hydrolyzed starch produces microcrystalline starch (MCS) with improved functional properties in terms of flowability or compressibility. The aim of this study was to investigate the binder, disintegrant and compressional properties of native and modified starches derived form of Digitaria iburua.

Digitaria iburua grains were collected and identified by the herbarium unit of Department of Biological Sciences, Ahmadu Bello University, Zaria. Digitaria iburua st...

310. EVALUATION OF SOME NATURAL AND SYNTHETIC PRODUCTS AGAINST AFRICAN TRYPANOSOMIASIS

ABSTRACT

The chemotherapy of African trypanosomiasis, a fatal protozoal disease of man and animals is beset with many problems including a limited repertoire of expensive compounds, drug toxicity and resistance and protracted treatment protocols. In order to improve chemotherapy, some natural and synthetic products were evaluated against African trypanosomiasis using in vitro and in vivo assays. Honey, extracts of Brassica oleracea and of frog and snakes (viper and cobra) skins were...

311. EVALUATION OF SOME CYTOKINES AND IRON LEVELS IN PREGNANT AND POST PARTUM WOMEN WITH MALARIA PARASITAEMIA IN ABA NIGERIA

1.1INTRODUCTION

The term pregnancy refers to a state in which fertilized ovum implants into the maternal uterus and develops into a foetus.The period of development and growth of the foetus is known as gestation. During gestation, normal physiological processes such as changes in the cytokine profile, increased erythropoiesis and thrombocytopenia take place in the maternal subjects. Often, most of these processes become pathological and may complicate or threaten the well-being and...

312. EVALUATION OF SIGNFICANCE OF HOUSING FINANCING MODELS TO DELIVERY

ABSTRACT

Housing is an integral element of a nation economy. Thus, focus on finance for housing projects has been more prominent due to huge financial resources that is required for provision of decent houses which is practically not at the disposal of low income earners in Nigeria. The aim of this study is to evaluate the effect of housing financing models on the delivery of housing project with a view to enhance availability and affordability of houses for low and middle income cl...

313. EVALUATION OF PULVERIZED COCONUT SHELL CHARCOAL AND PERIWINKLE SHELL FOR CARBURIZING MILD STEEL

ABSTRACT

The service conditions of many moving steel components require it to possess both hard and wear resistant surfaces witha tough and shock resistant cores. To achieve this, the suitability of pulverized coconut shell charcoal and periwinkle shell for carburizing 0.08%C mild steel was investigated in order to evaluate the carburizing parameters of the mild steel. The carburizing parameters evaluated were temperature, time and materials (ratio 75wt% pulverized coconut shell cha...

314. EVALUATION OF PHYSICOCHEMICAL, POLYMERIC AND METAL CONTENTS OF SELECTED TROPICAL TIMBERS IN NIGERIA

ABSTRACT

The qualitative and quantitative phytochemical analyses of 50 timbers of Nigeria were carried out. The physicchemical properties such as polymeric test, phytochemical test, solubility test, proximate analyses, saponification value, iodine value, acid value and peroxide value and elemental analyses of the wood species were determined. Results showed that the range of experimental values of the chemicals as well as other physical parameters were: moisture content (9.2 ±...

315. EVALUATION OF NOOTROPIC ACTIVITY OF METHANOL STEM EXTRACT OF PARQUETINA NIGRESCENS AFZEL IN MICE

ABSTRACT

Parquetina nigrescens is a plant with numerous ethnomedicinal uses in African traditional medicine practice. In the South Western part of Nigeria, the stems and roots are roasted, powdered then mixed with pap taken as memory enhancer and for its antiaging effect. This study therefore, aimed to investigate the nootropic activity of the methanol stem extract of P. nigrescens. Phytochemical screening was carried out on the methanol extract and the median lethal dose (LD50) det...

316. EVALUATION OF PHARMACOGNOSTICPARAMETERS AND HEPATOTOXIC EFFECTS OF EXTRACTSOF CASSYTHA FILIFORMIS LINN ON PARACETAMOL-INDUCED LIVER DISORDERS IN WISTER RATS

ABSTRACT

Cassytha filiformis, a leafless and perennial vine with small scales as a replacement of the leavesis currently being used in the treatment of various disease conditions including jaundice without standardization.Microscopical evaluation, chromatographic analysis (TLC, HPLC, LC-MS/MS), spectroscopic analyses (NMR, FTIR, MS) and hepathoprotective studies were carried out with the view to scientifically verify the potentials of this plant used in traditional medicine. The res...

317. EVALUATION OF PHARMACIST’S INTERVENTION ON KNOWLEDGE, ATTITUDE AND PRACTICES OF HYPERTENSIVE PATIENTS ON LIFESTYLE AND DIETARY MODIFICATIONS IN A TERTIARY HEALTH FACILITY IN NORTH-EASTERN NIGERIA

ABSTRACT

Hypertension is a major public health problem, which is growing in prevalence and poorly controlled worldwide. The prevalence is high in Nigeria and there is generally low level of awareness and practices of lifestyle and diet modification measures. The study was conducted from August 2016 to April 2017 to assess patient‘s knowledge, attitude and practices of lifestyle and diet at the University of Maiduguri teaching hospital (UMTH). Patients attending the cardiology...

318. EVALUATION OF PHARMACIST INTERVENTIONS ON TREATMENT OUTCOMES OF PULMONARY TUBERCULOSIS PATIENTS IN SECONDARY HEALTH FACILITIES ABUJA

ABSTRACT

Tuberculosis is a chronic infection that still remains one of the major health problems in most developing countries. Poor treatment outcomes have serious consequences which include spread of the disease, morbidity and mortality. The world health organization (WHO) recommended minimum successful outcomes of 85%; this has not been achieved in most facilities rendering the services. The aim of the study was to evaluate the impact of Pharmacist Intervention on the treatment ou...

319. EVALUATION OF MOLLUSCICIDAL ACTIVITIES OF CRUDE AND ALKALOIDAL FRACTION OF ANOGEISSUS LEIOCARPUS (AFRICAN BITCH) AND PSEUDOCEDRELA KOTSCHYI (DRY ZONE CEDAR) ON VECTOR OF SCHISTOSOMIASIS

ABSTRACT

Over the years, the use of plant-based molluscicides has received substantial consideration in the satisfaction for cost-effective alternatives to chemotherapy and synthetic molluscicides in schistosomiasis control. This study was aimed at evaluating the molluscicidal potentials of crude and Alkaloidal fractions of Anogeissus leiocarpus and Pseudocedrela kostchyi against vector of schistosomiasis. Both aqueous and methanol crude extracts of the plants were tested for the pr...

320. EVALUATION OF MILLET STARCHES (Pennisetum glaucum and Pennisetum americanum) AS TABLET BINDERS AND DISINTEGRANTS

Abstract

Starch was extracted from the two varieties of millet (Pennisetum glaucum and Pennisetum americanum) by the wet extraction method, the percentage yield was determined. The physicochemical properties investigated includes: flow rate, angle of repose, carr’s index, tapped density, bulk density, moisture content, swelling capacity, particle size, solubility, iodine test, and hausner ratio. Granules were prepared by the wet granulation method of massing and screening usin...

321. EVALUATION OF MANAGEMENT PRACTICES OF COLLEGES OF EDUCATION IN NORTH CENTRAL GEO - POLITICAL ZONE, NIGERIA

ABSTRACT

This study, “Evaluation of Management Practices of Colleges of Education in North Central Geo- Political Zone, Nigeria” was carried out with a view to providing the information on how Colleges of Education were managed in the area of study. The objectives of the study were to identify how planning strategies, staff development, decision making, communication, management of fund, provision of facilities, staffing, discipline and interpersonal relationships in Col...

322. EVALUATION OF HEAVY METALS, SOME ORGANIC AND MICROBIAL CONTAMINANTS IN THE EFFLUENTS FROM SOME FOOD INDUSTRIES IN ANAMBRA STATE, NIGERIA

ABSTRACT

This study was carried out to evaluate the concentrations of heavy metals and other contaminants in the effluents from some food industries in Anambra State. Effluents from Life Breweries, Onitsha; KP beverages, Ogidi; Obisco beverages, Ogidi; Golden Vegetable Oil, Onitsha and Resource Improvement and Manufacturing Company (RIMCO Nnewi) in Anambra State were sampled for a period of eight months ±four months rainy season and four months dry season ±for comparis...

323. EVALUATION OF LEAF BASE EXTRACT OF SORGHUM BICOLOR (FAMILY: GRAMINEAE; POACEAE) FOR HAEMATOLOGICAL, IMMUNOMODULATORY AND OTHER PHARMACOLOGICAL ACTIVITIES

ABSTRACT

Sorghum bicolor is an annual plant having its different parts widely used ethnomedicinally for different ailments, which includes blood stimulation and body defence. A number of clinical conditions like cancer, surgery, certain drugs, HIV/AIDS and various stressors affect different components of the immune system thereby allowing opportunistic pathogens to overwhelm the host leading to secondary infections and mortality in such individuals. This therefore shows a great need...

324. EVALUATION OF LEADERSHIP STYLES OF PRINCIPALS OF SECONDARY SCHOOLS IN ZONKWA EDUCATION ZONE, KADUNA STATE

ABSTRACT

The study entitled the Evaluation of Prevailing Leadership Styles in Zonkwa Education Zone Secondary Schools, Kaduna State has six objectives some of which are the assessment of the autocratic, transformational and situational leadership styles. Six research questions were asked in line with the objectives. Six null hypotheses were postulated some of which are that there is no significant difference in the opinions of respondents on the evaluation of the prevailing visionar...

325. EVALUATION OF INSITU GEOTECHNICAL PROPERTIES OF ROAD PAVEMENT LAYERS MATERIAL: A CASE STUDY OF MINNA–BIDA ROAD.

ABSTARCT

The intrinsic suitability of some lateritic soils as materials for construction of layers for flexible pavements is evaluated herein. The pavement layers assessed were the base course, sub-base and sub-grade. Laboratory results of samples from these layers show that the CBR values of the sub-grade materials met the requirement while about 40% and 70% of the locations for sub-base and base materials respectively, presented CBR values less than those specifie...